We are undertaking a number of studies to investigate the relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis and neuropathic pain and to identify predictors of response.
These studies include:
- Conventional meta-analyses of placebo-controlled RCTs comparing treatment and placebo and overall treatment effects.
- Bayesian network meta-analysis comparing treatments via placebo.
- Individual Patient Data (IPD) meta-analysis to examine predictors of response.
- A pilot n-of-1 trial series to examine treatment effects, patient preferences, and predictors of response.
Monica S M Persson, Joanne Stocks, Gyula Varadi, Mohammad Hashem Hashempur, Marienke van Middelkoop, Sita Bierma-Zeinstra, David A Walsh, Michael Doherty, Weiya Zhang, Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials, Rheumatology, Volume 59, Issue 9, September 2020, Pages 2207–2216, https://doi.org/10.1093//keaa113 [PDF]