Osteoarthritis biomarkers following combat blast injuries: First results from BioMilOA study published

Excited to announce our open-access paper ‘Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study‘ has been published in this month’s Osteoarthritis and Cartilage journal.

I am proud to be joint first author alongside Ollie O’Sullivan with joint senior authors Stefan Kluzek and Ana Valdes from the University of Nottingham.

The BioMilOA study (Biomarkers in Military Osteoarthritis) explores the relationship between osteoarthritis biomarkers and radiographic knee OA in a high-risk demographic of combat-injured soldiers.

BioMilOA is a Versus Arthritis funded sub-study of ADVANCE (The ArmeD SerVices TrAuma RehabilitatioN OutComE study which is investigating long-term combat-injury outcomes.

Key findings include:
1️⃣ Higher COMP levels in combat-injured participants.
2️⃣ Correlations between leptin (higher) and adiponectin (lower) with knee pain and painful radiographic OA.
3️⃣ Insights into OA similarities across participants, with key biomarker differences tied to trauma and pain.

🖼️ Check out the infographic summarizing this work, and read the full paper in Osteoarthritis and Cartilage, Volume 32, Issue 12, pages 1636–1646:
https://doi.org/10.1016/j.joca.2024.07.016