Angiogenesis and Airway Smooth Muscle

The following work was undertaken during my PhD in Respiratory Medicine at the University of Nottingham, under the supervision of Prof Alan Knox.My thesis research investigated the ‘Production of soluble angiogenic factors by airway smooth muscle’. During my PhD, I was also awarded a Universitas 21 scholarship to spend time working in the laboratories of Prof Alastair Stewart at the University of Melbourne’s Department of Pharmacology.

 
Journal Articles
 
Knox A, Corbett L, Stocks J, Holland E, Zhu Y, Pang L. Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism. FASEB J. 2001 Nov 1;15(13):2480–8. [PubMed] [PDF}
 
Bradbury D, Newton R, Zhu Y, Stocks J, Corbett L, Holland E, Pang L, Knox A. Effect of bradykinin, TGF-beta1, IL-1beta, and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2002 Oct 1;283(4):L717-25. [PubMed] [PDF]
 
Bradbury D, Clarke D, Seedhouse C, Corbett L, Stocks J, Knox A. Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites. J Biol Chem. 2005 Aug 26;280(34):29993–30000. [PubMed] [PDF]
 
Stocks J, Bradbury D, Corbett L, Pang L, Knox A. Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids. FEBS Lett. 2005 May 9;579(12):2551–6. [PubMed] [PDF]
 

Editorial

Knox A, Stocks J, Sutcliffe A. Angiogenesis and vascular endothelial growth factor in COPD. Thorax. 2005 Feb 1;60(2):88–9. [PubMed] [PDF]
 

Conference Abstracts

British Thoracic Society Conference 2001

Bradbury D, Pang L, Holland E, Stocks J, Knox A. Effect of hypoxia on bradykinin, IL-1β and TGF-β1 induced COX-2 expression and PGE2 release in human pulmonary artery smooth muscle cells THORAX 56: S112 Suppl. 3 DEC (2001)

American Thoracic Society Conference 2002

L. Corbett, J. Stocks, L. Pang, A.J. Knox. TGF-β increases VEGF release from cultured human airway smooth muscle cells: Regulation by steroids and beta agonists. American Journal of Respiratory and Critical Care Medicine (165) A114 (2002)

American Thoracic Society Conference 2003

J. Stocks, L. Corbett, L. Pang and A. J. Knox. IL-1β but not TGF-β releases VEGF through prostanoid dependent pathways. American Journal of Respiratory and Critical Care Medicine [7], A571 (2003).

American Thoracic Society Conference 2004

J. Stocks, D. Bradbury, A.J. Knox. Expression of Angiopoietins and Tie-2 in Human Airway Smooth Muscle. American Journal of Respiratory and Critical Care Medicine 169 [7], A188 (2004).

American Thoracic Society Conference 2004

J. Stocks, D. Bradbury, M. Nie, L. Pang, A.J. Knox. Regulation of VEGF-A Expression in Human Airway Smooth Muscle by bradykinin, TGFβ and IL-1β American Journal of Respiratory and Critical Care Medicine 169 [7], A849 (2004).

American Thoracic Society Conference 2005

D.A. Bradbury, J. Stocks, L.M. Corbett, D.L. Clarke, A.J. Knox. Vascular Endothelial Growth Factor Induction by PGE2 in Human Airway Smooth Muscle Cells Is Mediated by EP2/EP4 Receptors and Sp-1 Transcription Factor Binding Sites. Proceedings of the American Thoracic Society. Vol 2 A240 (2005).

Conference Oral Presentations

2005 American Thoracic Society International Conference, San Diego

Thrombin Induces VEGF Production in Airway Smooth Muscle Via Prostanoid and PAR-1/4 Independent Mechanisms. Proceedings of the American Thoracic Society. Vol 2 A27 (2005) [PDF]