The Knee Pain In the Community (KPIC) cohort was established through questionnaire responses from over 9,000 members of the local Nottingham community. Using yearly follow-up questionnaires this study will determine the natural history of knee pain and knee osteoarthritis and the reasons why some individuals develop severe pain and others do not.
Alongside extensive phenotypic characterisation of participants, including: age of symptom onset; the distribution of pain and joint changes throughout the body; detailed self-reported lifestyle factors; and co-morbidities, in a sub-sample of 400 participants we also have radiographs and knee ultrasound, pain pressure thresholds, muscle function and gait recordings.
Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort Daniel F.McWilliams, Bin Yue, Stephanie L. Smith, Joanne Stocks, Michael Doherty, Ana M. Valdes, Weiya Zhang, Aliya Sarmanova, Gwen S. Fernandes, Kehinde Akin-Akinyosoye, Michelle Hall, David A Walsh. Journal of Personalized Medicine 13, no. 10: 1450. [PDF]
Baseline self-report ‘central mechanisms’ trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort. Kehinde Akin-Akinyosoye, Aliya Sarmonova, Nadia Frowd, Laura Marshall, Joanne Stocks, Gwen S Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson, David A Walsh. Osteoarthritis and Cartilage (2020) 28 (2)173–181 [PDF]
The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation. Burston J, Valdes A, Woodhams S, Mapp P, Stocks J, Watson D, Gowler P, Xu L, Sagar D, Fernandes G, Frowd N, Marshall L, Zhang W, Doherty M, Walsh D, Chapman V. Pain. 2019 Mar 1;160(3):658–69. [PDF]
Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort. Akin-Akinyosoye K, Frowd N, Marshall L, Stocks J, Fernandes G, Valdes A, McWilliams D, Zhang W, Doherty M, Ferguson E, Walsh D. Pain. 2018 Jun 1;159(6):1035–44. [PDF]
Knee pain and related health in the community study (KPIC): a cohort study protocol. Fernandes G, Sarmanova A, Warner S, Harvey H, Akin-Akinyosoye K, Richardson H, Frowd N, Marshall L, Stocks J, Hall M, Valdes A, Walsh D, Zhang W, Doherty M. BMC Musculoskelet Disord. 2017 Sep 21;18(1):404.[PDF]
Associations of peripheral and central pain mechanisms with voluntary muscle strength in people with knee pain. Bin Yue, DanF McWilliams, Stephanie Smith, Joanne Stocks, Aliya Sarmanova, Gwen S Fernandes, Laura Swaithes, Nadia Frowd, Michael Doherty, Weiya Zhang, Ana M Valdes, Michelle Hall, David A Walsh Osteoarthritis and Cartilage April 2021 29 S366-367 [PDF]
Pain distant from the index site and sensitization in people with knee pain and low back pain. Kehinde Akin-Akinyosoye, Vas Georgopoulos, Nadia Frowd, Laura Swaithes, Joanne Stocks, Gwen Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson David Walsh Osteoarthritis and Cartilage April 2020 28 S375 [PDF]
Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort R. Matthews, Kehinde Akin-Akinyosoye, Nadia Frowd, Laura Swaithes, Joanne Stocks, Gwen Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson David Walsh Osteoarthritis and Cartilage April 2020 28 S362 [PDF]
159 Self-report central mechanisms trait predicts knee pain persistence in the Knee Pain In the Community (KPIC) cohort. Kehinde Akin-Akinyosoye, Nadia Frowd, Laura Swaithes, Joanne Stocks, Aliya Sarmanova, Gwen Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson David Walsh Rheumatology, Volume 58, Issue Supplement_3, April 2019 [PDF]
THU0519 Prediction of persistent knee pain by pressure pain detection thresholds: results from the knee pain in the community cohort (KPIC) Daniel F McWilliams, Nadia Frowd, Laura Marshall, Joanne Stocks, Aliya Sarmanova, Gwen Sascha Fernandes, M Hall, Weiya Zhang, Michael Doherty, AM Valdes, DA Walsh. Annals of the Rheumatic Diseases 77 (Suppl 2), 464 [PDF]
A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis. K. Akin-Akinyosoye, N. Frowd, L. Marshall, J. Stocks, G.S. Fernandes, A. Valdes, D.F. McWilliams, W. Zhang, M. Doherty, E. Ferguson, D. Walsh. Osteoarthritis and Cartilage April 2018 26, S231-S232 [PDF]
SAT 0670 The prevalence of neuropathic pain-like symptoms and associated risk factors in the Nottingham community: a cross-sectional study. GS Fernandes, A Sarmanova, S Warner, H Harvey, H Richardson, N Frowd, L Marshall, J Stocks, M Hall, A Valdes, D Walsh, W Zhang, M Doherty. Annals of the Rheumatic Diseases.76:Suppl 2; 1028 (2017) [PDF]
Pain distribution as an indicator of central mechanisms in Knee Osteoarthritis (OA) pain. K. Akin-Akinyosoye, N. Frowd, L. Marshall, J. Stocks, G.S. Fernandes, A. Valdes, D.F. McWilliams, W. Zhang ,M. Doherty, E. Ferguson, D. Walsh Br J Pain. 2017 May; 11(2 Suppl): 5–96.